Serum Inhibin A and Inhibin B Levels in Epithelial Ovarian Cancer Patients
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منابع مشابه
Serum Inhibin A and Inhibin B Levels in Epithelial Ovarian Cancer Patients
THE AIM of our study was to examine serum inhibin A and inhibin B concentrations in ovarian cancer patients in relation to clinicopathological features and 5-year survival. MATERIAL AND METHODS We enrolled 90 epithelial ovarian cancer patients in our study, aged 45-81 years, who underwent optimal cytoreductive surgery. In all patients, serum inhibin A and inhibin B concentrations were measure...
متن کاملInhibin/activin and ovarian cancer.
Inhibin and activin are members of the transforming growth factor beta (TGFbeta) family of cytokines produced by the gonads, with a recognised role in regulating pituitary FSH secretion. Inhibin consists of two homologous subunits, alpha and either betaA or betaB (inhibin A and B). Activins are hetero- or homodimers of the beta-subunits. Inhibin and free alpha subunit are known products of two ...
متن کاملIs inhibin a serum marker for ovarian cancer?
Research endocrinologists are well aware of inhibin and the family of proteins of which it is a part. Inhibin was discovered almost 70 years ago as a product of the gonads that selectively inhibited the secretion of folliclestimulating hormone (FSH) at the level of the pituitary gland. We now know that inhibin is present in at least two biologically active forms (inhibin A and B) as well as in ...
متن کاملComparison of follicular fluid and serum levels of Inhibin A and Inhibin B with calculated indices used as predictive markers of ovarian hyperstimulation syndrome in IVF patients
BACKGROUND Ovarian Hyperstimulation Syndrome (OHSS) is a severe health complication observed in some patients undergoing hormonal stimulation during IVF. Presence of OHSS is often associated with a high count of growing follicles responding to FSH hyperstimulation. However, the number of responding follicles may not be sufficient enough to predict the onset and severity of OHSS. The aim of this...
متن کاملPresence of activin, inhibin, and follistatin in epithelial ovarian carcinoma.
Activin induces proliferation in epithelial ovarian carcinoma cell lines, whereas follistatin (FS), an activin binding protein, inhibits this action. To test the hypothesis that activin production, in excess of inhibin and FS, results in cell proliferation in epithelial ovarian tumors, messenger RNA (mRNA) expression of the activin family of proteins, FS, and activin type I and II receptors was...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0090575